ThunderEase Calming Pheromones mimics the properties of the natural pheromones of the lactating female. Within three to five days after giving birth, the female generates pheromones that give their puppies a sense of well-being and reassurance, known as appeasing pheromones. By replicating this signal of comfort, ThunderEase helps alleviate fear and stress related signs in the puppy and adult dog such as: travel/transportation anxiety, noise anxiety, being left home alone, socialization, puppy training, boarding and grooming, etc. See packaging for complete product details.